Assay Detail
Binding
CHEMBL4345980
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Binding affinity to HIV1 NL4-3 capsid protein monomer by SPR analysis
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Structural capsid protein (CHEMBL2366504) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Design, Synthesis, and Mechanism Study of Benzenesulfonamide-Containing Phenylalanine Derivatives as Novel HIV-1 Capsid Inhibitors with Improved Antiviral Activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 8 | 5.21 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4559349 | — | — | 1 | 6.70 |
| CHEMBL1229713 | — | — | 1 | 5.55 |
| CHEMBL4436876 | — | — | 1 | 5.18 |
| CHEMBL4573304 | — | — | 1 | 5.00 |
| CHEMBL4566312 | — | — | 1 | 4.94 |
| CHEMBL4471665 | — | — | 1 | 4.87 |
| CHEMBL4543615 | — | — | 1 | 4.81 |
| CHEMBL4571968 | — | — | 1 | 4.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4559349 | — | Kd | = | 200.0 | nM | 6.70 |
| CHEMBL1229713 | — | Kd | = | 2800.0 | nM | 5.55 |
| CHEMBL4436876 | — | Kd | = | 6630.0 | nM | 5.18 |
| CHEMBL4573304 | — | Kd | = | 10000.0 | nM | 5.00 |
| CHEMBL4566312 | — | Kd | = | 11500.0 | nM | 4.94 |
| CHEMBL4471665 | — | Kd | = | 13600.0 | nM | 4.87 |
| CHEMBL4543615 | — | Kd | = | 15500.0 | nM | 4.81 |
| CHEMBL4571968 | — | Kd | = | 22100.0 | nM | 4.66 |