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Assay Detail

CHEMBL4346860

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [3H]MSX-2 from recombinant human A2A adenosine receptor expressed in CHO cell membranes measured after 60 mins by liquid scintillation counting method
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Cell Type CHO
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Adenosine receptor A2a (CHEMBL251)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

A<sub>2B</sub> Adenosine Receptor Antagonists with Picomolar Potency.
Jiang J, Seel CJ, Temirak A, Namasivayam V, Arridu A, Schabikowski J, Baqi Y, Hinz S, Hockemeyer J, Müller CE.
J Med Chem (2019) 62 : 4032 -4055
PubMed 30835463 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 1 5.42 5.42

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL8565 1 5.42

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL8565 Ki = 3790.0 nM 5.42