Assay Detail
Functional
CHEMBL4348055
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Antiinflammatory activity in C57BL/6J mouse Primary peritoneal macrophages assessed as inhibition of LPS-stimulated IL-6 expression preincubated for 30 mins followed by LPS stimulation measured after 24 hrs by ELISA
8
Total Activities
4
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | Peritoneal macrophage |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Base promoted synthesis of novel indole-dithiocarbamate compounds as potential anti-inflammatory therapeutic agents for treatment of acute lung injury.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.28 | 7.84 |
| Inhibition | 4 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4573465 | — | — | 2 | 7.84 |
| CHEMBL4471265 | — | — | 2 | 7.15 |
| CHEMBL4451891 | — | — | 2 | 7.06 |
| CHEMBL4537850 | — | — | 2 | 7.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4573465 | — | IC50 | = | 14.6 | nM | 7.84 |
| CHEMBL4471265 | — | IC50 | = | 70.7 | nM | 7.15 |
| CHEMBL4451891 | — | IC50 | = | 87.6 | nM | 7.06 |
| CHEMBL4537850 | — | IC50 | = | 87.4 | nM | 7.06 |
| CHEMBL4471265 | — | Inhibition | - | % | - | |
| CHEMBL4573465 | — | Inhibition | - | % | - | |
| CHEMBL4451891 | — | Inhibition | - | % | - | |
| CHEMBL4537850 | — | Inhibition | - | % | - |