Assay Detail
Functional
CHEMBL4348246
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Antiproliferative activity against human HCT116 cells deficient in p53 incubated for 72 hrs by MTS assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Anticancer activity of the thiosemicarbazones that are based on di-2-pyridine ketone and quinoline moiety.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 6.82 | 8.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL385064 | — | — | 1 | 8.96 |
| CHEMBL4547135 | — | — | 1 | 8.00 |
| CHEMBL4521459 | — | — | 1 | 7.85 |
| CHEMBL4587686 | — | — | 1 | 7.82 |
| CHEMBL4539081 | — | — | 1 | 7.72 |
| CHEMBL4435401 | — | — | 1 | 7.19 |
| CHEMBL4438261 | — | — | 1 | 7.16 |
| CHEMBL4540209 | — | — | 1 | 6.85 |
| CHEMBL4468050 | — | — | 1 | 6.85 |
| CHEMBL4450861 | — | — | 1 | 6.82 |
| CHEMBL4455620 | — | — | 1 | 6.75 |
| CHEMBL4448539 | — | — | 1 | 6.66 |
| CHEMBL4584891 | — | — | 1 | 6.64 |
| CHEMBL4440736 | — | — | 1 | 6.54 |
| CHEMBL4448387 | — | — | 1 | 6.37 |
| CHEMBL4474864 | — | — | 1 | 5.87 |
| CHEMBL4454477 | — | — | 1 | 5.23 |
| CHEMBL4570024 | — | — | 1 | 5.20 |
| CHEMBL4552738 | — | — | 1 | 5.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL385064 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL4547135 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4521459 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4587686 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL4539081 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL4435401 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL4438261 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL4540209 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL4468050 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL4450861 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL4455620 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL4448539 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL4584891 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL4440736 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL4448387 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL4474864 | — | IC50 | = | 1340.0 | nM | 5.87 |
| CHEMBL4454477 | — | IC50 | = | 5850.0 | nM | 5.23 |
| CHEMBL4570024 | — | IC50 | = | 6270.0 | nM | 5.20 |
| CHEMBL4552738 | — | IC50 | = | 8420.0 | nM | 5.08 |