Assay Detail
Binding
CHEMBL4348307
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Inhibition of Escherichia coli FabH in presence of radiolabelled substrates and acetyl-coA by enzyme coupled FabD/FabH assay system
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
3-oxoacyl-[acyl-carrier-protein] synthase 3 (CHEMBL1795135) ↗| Type | SINGLE PROTEIN |
| Organism | Escherichia coli |
Publication
Discovery of novel bacterial FabH inhibitors (Pyrazol-Benzimidazole amide derivatives): Design, synthesis, bioassay, molecular docking and crystal structure determination.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 4.72 | 5.91 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4446312 | — | — | 1 | 5.91 |
| CHEMBL4514635 | — | — | 1 | 5.69 |
| CHEMBL4476826 | — | — | 1 | 5.51 |
| CHEMBL4469459 | — | — | 1 | 5.40 |
| CHEMBL4537282 | — | — | 1 | 5.02 |
| CHEMBL4535737 | — | — | 1 | 4.82 |
| CHEMBL4549786 | — | — | 1 | 4.77 |
| CHEMBL4463666 | — | — | 1 | 4.74 |
| CHEMBL4453189 | — | — | 1 | 4.66 |
| CHEMBL4471509 | — | — | 1 | 4.66 |
| CHEMBL4587004 | — | — | 1 | 4.64 |
| CHEMBL4550391 | — | — | 1 | 4.59 |
| CHEMBL4519890 | — | — | 1 | 4.55 |
| CHEMBL4589947 | — | — | 1 | 4.52 |
| CHEMBL4593863 | — | — | 1 | 4.52 |
| CHEMBL4542273 | — | — | 1 | 4.50 |
| CHEMBL4449529 | — | — | 1 | 4.49 |
| CHEMBL4446325 | — | — | 1 | 4.48 |
| CHEMBL4538507 | — | — | 1 | 4.47 |
| CHEMBL4463245 | — | — | 1 | 4.47 |
| CHEMBL4459693 | — | — | 1 | 4.46 |
| CHEMBL4475489 | — | — | 1 | 4.45 |
| CHEMBL4579677 | — | — | 1 | 4.44 |
| CHEMBL4542719 | — | — | 1 | 4.44 |
| CHEMBL4522020 | — | — | 1 | 4.43 |
| CHEMBL4515120 | — | — | 1 | 4.42 |
| CHEMBL4457694 | — | — | 1 | 4.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4446312 | — | IC50 | = | 1220.0 | nM | 5.91 |
| CHEMBL4514635 | — | IC50 | = | 2050.0 | nM | 5.69 |
| CHEMBL4476826 | — | IC50 | = | 3060.0 | nM | 5.51 |
| CHEMBL4469459 | — | IC50 | = | 4020.0 | nM | 5.40 |
| CHEMBL4537282 | — | IC50 | = | 9560.0 | nM | 5.02 |
| CHEMBL4535737 | — | IC50 | = | 15230.0 | nM | 4.82 |
| CHEMBL4549786 | — | IC50 | = | 16880.0 | nM | 4.77 |
| CHEMBL4463666 | — | IC50 | = | 18330.0 | nM | 4.74 |
| CHEMBL4453189 | — | IC50 | = | 22080.0 | nM | 4.66 |
| CHEMBL4471509 | — | IC50 | = | 22090.0 | nM | 4.66 |
| CHEMBL4587004 | — | IC50 | = | 22890.0 | nM | 4.64 |
| CHEMBL4550391 | — | IC50 | = | 25650.0 | nM | 4.59 |
| CHEMBL4519890 | — | IC50 | = | 28230.0 | nM | 4.55 |
| CHEMBL4589947 | — | IC50 | = | 30280.0 | nM | 4.52 |
| CHEMBL4593863 | — | IC50 | = | 30330.0 | nM | 4.52 |
| CHEMBL4542273 | — | IC50 | = | 31820.0 | nM | 4.50 |
| CHEMBL4449529 | — | IC50 | = | 32670.0 | nM | 4.49 |
| CHEMBL4446325 | — | IC50 | = | 33170.0 | nM | 4.48 |
| CHEMBL4538507 | — | IC50 | = | 34110.0 | nM | 4.47 |
| CHEMBL4463245 | — | IC50 | = | 33880.0 | nM | 4.47 |
| CHEMBL4459693 | — | IC50 | = | 34860.0 | nM | 4.46 |
| CHEMBL4475489 | — | IC50 | = | 35410.0 | nM | 4.45 |
| CHEMBL4579677 | — | IC50 | = | 36450.0 | nM | 4.44 |
| CHEMBL4542719 | — | IC50 | = | 36090.0 | nM | 4.44 |
| CHEMBL4522020 | — | IC50 | = | 37230.0 | nM | 4.43 |
| CHEMBL4515120 | — | IC50 | = | 38240.0 | nM | 4.42 |
| CHEMBL4457694 | — | IC50 | = | 39810.0 | nM | 4.40 |