Assay Detail
Functional
CHEMBL4348484
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Cytotoxicity against human NCI-H2228 cells incubated for 72 hrs by MTT assay
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H2228 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of novel mutant-combating ALK and ROS1 dual inhibitors bearing imidazolidin-2-one moiety with reasonable PK properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 30 | 6.43 | 7.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4470529 | — | — | 1 | 7.43 |
| CHEMBL4447747 | — | — | 1 | 7.39 |
| CHEMBL4464571 | — | — | 1 | 7.04 |
| CHEMBL4586917 | — | — | 1 | 6.92 |
| CHEMBL4554640 | — | — | 1 | 6.82 |
| CHEMBL2403108 | CERITINIB | 4.0 | 1 | 6.82 |
| CHEMBL4450345 | — | — | 1 | 6.77 |
| CHEMBL4519546 | — | — | 1 | 6.64 |
| CHEMBL4554368 | — | — | 1 | 6.57 |
| CHEMBL601719 | CRIZOTINIB | 4.0 | 1 | 6.57 |
| CHEMBL4472611 | — | — | 1 | 6.50 |
| CHEMBL4452463 | — | — | 1 | 6.50 |
| CHEMBL4557617 | — | — | 1 | 6.46 |
| CHEMBL4465558 | — | — | 1 | 6.46 |
| CHEMBL4573193 | — | — | 1 | 6.43 |
| CHEMBL4456460 | — | — | 1 | 6.38 |
| CHEMBL4519408 | — | — | 1 | 6.28 |
| CHEMBL4466920 | — | — | 1 | 6.28 |
| CHEMBL4518307 | — | — | 1 | 6.28 |
| CHEMBL4456914 | — | — | 1 | 6.24 |
| CHEMBL4461727 | — | — | 1 | 6.21 |
| CHEMBL4590579 | — | — | 1 | 6.17 |
| CHEMBL4437262 | — | — | 1 | 6.12 |
| CHEMBL4463949 | — | — | 1 | 6.06 |
| CHEMBL4558432 | — | — | 1 | 6.06 |
| CHEMBL4437160 | — | — | 1 | 6.04 |
| CHEMBL4523049 | — | — | 1 | 6.04 |
| CHEMBL4473467 | — | — | 1 | 5.95 |
| CHEMBL4575542 | — | — | 1 | 5.82 |
| CHEMBL4445053 | — | — | 1 | 5.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4470529 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL4447747 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL4464571 | — | IC50 | = | 92.0 | nM | 7.04 |
| CHEMBL4586917 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL4554640 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL2403108 | CERITINIB | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL4450345 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL4519546 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL4554368 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL601719 | CRIZOTINIB | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL4472611 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL4452463 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL4557617 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL4465558 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL4573193 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL4456460 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL4519408 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL4466920 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL4518307 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL4456914 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL4461727 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL4590579 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL4437262 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL4463949 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL4558432 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL4437160 | — | IC50 | = | 910.0 | nM | 6.04 |
| CHEMBL4523049 | — | IC50 | = | 920.0 | nM | 6.04 |
| CHEMBL4473467 | — | IC50 | = | 1130.0 | nM | 5.95 |
| CHEMBL4575542 | — | IC50 | = | 1530.0 | nM | 5.82 |
| CHEMBL4445053 | — | IC50 | = | 1710.0 | nM | 5.77 |