Assay Detail
Functional
CHEMBL4348485
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against mouse BA/F3 cells harboring ALK G1202R mutation incubated for 72 hrs by MTT assay
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | BaF3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of novel mutant-combating ALK and ROS1 dual inhibitors bearing imidazolidin-2-one moiety with reasonable PK properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 30 | 6.10 | 7.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4470529 | — | — | 1 | 7.47 |
| CHEMBL4447747 | — | — | 1 | 7.16 |
| CHEMBL4573193 | — | — | 1 | 7.10 |
| CHEMBL4466920 | — | — | 1 | 7.03 |
| CHEMBL4437262 | — | — | 1 | 6.96 |
| CHEMBL4586917 | — | — | 1 | 6.80 |
| CHEMBL4465558 | — | — | 1 | 6.35 |
| CHEMBL4464571 | — | — | 1 | 6.34 |
| CHEMBL2403108 | CERITINIB | 4.0 | 1 | 6.00 |
| CHEMBL4450345 | — | — | 1 | 5.92 |
| CHEMBL4519408 | — | — | 1 | 5.86 |
| CHEMBL4590579 | — | — | 1 | 5.77 |
| CHEMBL4554368 | — | — | 1 | 5.71 |
| CHEMBL4456914 | — | — | 1 | 5.69 |
| CHEMBL4554640 | — | — | 1 | 5.60 |
| CHEMBL4473467 | — | — | 1 | 5.56 |
| CHEMBL4519546 | — | — | 1 | 5.55 |
| CHEMBL4518307 | — | — | 1 | 5.53 |
| CHEMBL4456460 | — | — | 1 | 5.49 |
| CHEMBL4575542 | — | — | 1 | 5.46 |
| CHEMBL4558432 | — | — | 1 | 5.46 |
| CHEMBL4452463 | — | — | 1 | 5.37 |
| CHEMBL4463949 | — | — | 1 | - |
| CHEMBL4437160 | — | — | 1 | - |
| CHEMBL601719 | CRIZOTINIB | 4.0 | 1 | - |
| CHEMBL4557617 | — | — | 1 | - |
| CHEMBL4472611 | — | — | 1 | - |
| CHEMBL4523049 | — | — | 1 | - |
| CHEMBL4461727 | — | — | 1 | - |
| CHEMBL4445053 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4470529 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL4447747 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL4573193 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL4466920 | — | IC50 | = | 94.0 | nM | 7.03 |
| CHEMBL4437262 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL4586917 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL4465558 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL4464571 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL2403108 | CERITINIB | IC50 | = | 1010.0 | nM | 6.00 |
| CHEMBL4450345 | — | IC50 | = | 1190.0 | nM | 5.92 |
| CHEMBL4519408 | — | IC50 | = | 1380.0 | nM | 5.86 |
| CHEMBL4590579 | — | IC50 | = | 1710.0 | nM | 5.77 |
| CHEMBL4554368 | — | IC50 | = | 1960.0 | nM | 5.71 |
| CHEMBL4456914 | — | IC50 | = | 2060.0 | nM | 5.69 |
| CHEMBL4554640 | — | IC50 | = | 2490.0 | nM | 5.60 |
| CHEMBL4473467 | — | IC50 | = | 2780.0 | nM | 5.56 |
| CHEMBL4519546 | — | IC50 | = | 2790.0 | nM | 5.55 |
| CHEMBL4518307 | — | IC50 | = | 2970.0 | nM | 5.53 |
| CHEMBL4456460 | — | IC50 | = | 3220.0 | nM | 5.49 |
| CHEMBL4575542 | — | IC50 | = | 3450.0 | nM | 5.46 |
| CHEMBL4558432 | — | IC50 | = | 3510.0 | nM | 5.46 |
| CHEMBL4452463 | — | IC50 | = | 4280.0 | nM | 5.37 |
| CHEMBL4463949 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4437160 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL601719 | CRIZOTINIB | IC50 | > | 5000.0 | nM | - |
| CHEMBL4557617 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4472611 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4523049 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4461727 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4445053 | — | IC50 | > | 5000.0 | nM | - |