Assay Detail
Binding
CHEMBL4349093
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Inhibition of TTK autophosphorylation in human CAL51 cells by radioimmuno-precipitation assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design and Optimization Leading to an Orally Active TTK Protein Kinase Inhibitor with Robust Single Agent Efficacy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.74 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4546504 | — | — | 1 | 8.05 |
| CHEMBL4521278 | — | — | 1 | 7.80 |
| CHEMBL4569626 | — | — | 1 | 7.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4546504 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL4521278 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL4569626 | — | IC50 | = | 44.0 | nM | 7.36 |