Assay Detail
Functional
CHEMBL4349205
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Neuroprotection against H2O2-induced cell death in human SH-SY5Y cells assessed as increase in cell viability preincubated for 1 hr followed by H2O2 addition and measured after 24 hrs by MTT assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SH-SY5Y |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of coumarin Mannich base derivatives as multifunctional agents against monoamine oxidase B and neuroinflammation for the treatment of Parkinson's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 12 | 4.66 | 5.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4525381 | — | — | 1 | 5.74 |
| CHEMBL4554567 | — | — | 1 | 4.71 |
| CHEMBL4546398 | — | — | 1 | 4.12 |
| CHEMBL4467621 | — | — | 1 | 4.08 |
| CHEMBL4541683 | — | — | 1 | - |
| CHEMBL4475218 | — | — | 1 | - |
| CHEMBL4466943 | — | — | 1 | - |
| CHEMBL4571403 | — | — | 1 | - |
| CHEMBL4463853 | — | — | 1 | - |
| CHEMBL4438112 | — | — | 1 | - |
| CHEMBL4439360 | — | — | 1 | - |
| CHEMBL4474002 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4525381 | — | EC50 | = | 1820.0 | nM | 5.74 |
| CHEMBL4554567 | — | EC50 | = | 19690.0 | nM | 4.71 |
| CHEMBL4546398 | — | EC50 | = | 75060.0 | nM | 4.12 |
| CHEMBL4467621 | — | EC50 | = | 83660.0 | nM | 4.08 |
| CHEMBL4541683 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL4475218 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL4466943 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL4571403 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL4463853 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL4438112 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL4439360 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL4474002 | — | EC50 | > | 100000.0 | nM | - |