Assay Detail
Binding
CHEMBL4349901
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]ifenprodil from human GluN2B expressed in mouse L(tk-) cell membranes co-expressing GluN1a incubated for 120 mins by scintillation counting method
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Glutamate receptor ionotropic, NMDA 2B (CHEMBL1904) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Modification of the 4-phenylbutyl side chain of potent 3-benzazepine-based GluN2B receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 7.02 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL113830 | (S,R)-IFENPRODIL | — | 1 | 8.00 |
| CHEMBL28564 | ELIPRODIL | 2.0 | 1 | 7.89 |
| CHEMBL4439555 | — | — | 1 | 6.71 |
| CHEMBL4472450 | — | — | 1 | 6.34 |
| CHEMBL1289403 | — | — | 1 | 6.15 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL113830 | (S,R)-IFENPRODIL | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL28564 | ELIPRODIL | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL4439555 | — | Ki | = | 193.0 | nM | 6.71 |
| CHEMBL4472450 | — | Ki | = | 460.0 | nM | 6.34 |
| CHEMBL1289403 | — | Ki | = | 706.0 | nM | 6.15 |