Assay Detail
Binding
CHEMBL4350375
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant GST-tagged MNK1 (unknown origin) using eIF4E-derived peptide as substrate in presence of ATP at km concentration by ADP-Glo assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
MAP kinase-interacting serine/threonine-protein kinase 1 (CHEMBL4718) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and evaluation of 2'H-spiro[cyclohexane-1,3'-imidazo[1,5-a]pyridine]-1',5'-dione derivatives as Mnk inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 7.46 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4439094 | — | — | 1 | 8.70 |
| CHEMBL4073443 | TOMIVOSERTIB | 2.0 | 1 | 8.30 |
| CHEMBL4449736 | — | — | 1 | 7.50 |
| CHEMBL4535537 | — | — | 1 | 7.12 |
| CHEMBL4454334 | — | — | 1 | 6.66 |
| CHEMBL4466664 | — | — | 1 | 6.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4439094 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL4073443 | TOMIVOSERTIB | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL4449736 | — | Ki | = | 32.0 | nM | 7.50 |
| CHEMBL4535537 | — | Ki | = | 76.0 | nM | 7.12 |
| CHEMBL4454334 | — | Ki | = | 221.0 | nM | 6.66 |
| CHEMBL4466664 | — | Ki | = | 341.0 | nM | 6.47 |