Assay Detail
ADMET
CHEMBL4350847
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Inhibition of human PDE4B catalytic domain using cAMP as substrate incubated for 20 mins by PDELight HTS cAMP phosphodiesterase Kit based luminometry
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
3',5'-cyclic-AMP phosphodiesterase 4B (CHEMBL275) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Alkynamide phthalazinones as a new class of TbrPDEB1 inhibitors (Part 2).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 25 | 6.25 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4439032 | — | — | 1 | 6.70 |
| CHEMBL4445489 | — | — | 1 | 6.60 |
| CHEMBL4465919 | — | — | 1 | 6.50 |
| CHEMBL4463356 | — | — | 1 | 6.50 |
| CHEMBL4565967 | — | — | 1 | 6.50 |
| CHEMBL4516631 | — | — | 1 | 6.40 |
| CHEMBL4453613 | — | — | 1 | 6.40 |
| CHEMBL4444414 | — | — | 1 | 6.40 |
| CHEMBL4471782 | — | — | 1 | 6.30 |
| CHEMBL4522881 | — | — | 1 | 6.30 |
| CHEMBL4445930 | — | — | 1 | 6.30 |
| CHEMBL4521383 | — | — | 1 | 6.30 |
| CHEMBL4439778 | — | — | 1 | 6.20 |
| CHEMBL4454951 | — | — | 1 | 6.20 |
| CHEMBL4435831 | — | — | 1 | 6.20 |
| CHEMBL4472788 | — | — | 1 | 6.10 |
| CHEMBL4439798 | — | — | 1 | 6.10 |
| CHEMBL4562476 | — | — | 1 | 6.10 |
| CHEMBL4473629 | — | — | 1 | 6.10 |
| CHEMBL4443772 | — | — | 1 | 6.10 |
| CHEMBL4436770 | — | — | 1 | 6.10 |
| CHEMBL4566533 | — | — | 1 | 6.00 |
| CHEMBL4453045 | — | — | 1 | 6.00 |
| CHEMBL4520014 | — | — | 1 | 5.90 |
| CHEMBL4583339 | — | — | 1 | 5.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4439032 | — | Ki | = | 199.53 | nM | 6.70 |
| CHEMBL4445489 | — | Ki | = | 251.19 | nM | 6.60 |
| CHEMBL4465919 | — | Ki | = | 316.23 | nM | 6.50 |
| CHEMBL4463356 | — | Ki | = | 316.23 | nM | 6.50 |
| CHEMBL4565967 | — | Ki | = | 316.23 | nM | 6.50 |
| CHEMBL4516631 | — | Ki | = | 398.11 | nM | 6.40 |
| CHEMBL4453613 | — | Ki | = | 398.11 | nM | 6.40 |
| CHEMBL4444414 | — | Ki | = | 398.11 | nM | 6.40 |
| CHEMBL4471782 | — | Ki | = | 501.19 | nM | 6.30 |
| CHEMBL4522881 | — | Ki | = | 501.19 | nM | 6.30 |
| CHEMBL4445930 | — | Ki | = | 501.19 | nM | 6.30 |
| CHEMBL4521383 | — | Ki | = | 501.19 | nM | 6.30 |
| CHEMBL4439778 | — | Ki | = | 630.96 | nM | 6.20 |
| CHEMBL4454951 | — | Ki | = | 630.96 | nM | 6.20 |
| CHEMBL4435831 | — | Ki | = | 630.96 | nM | 6.20 |
| CHEMBL4472788 | — | Ki | = | 794.33 | nM | 6.10 |
| CHEMBL4439798 | — | Ki | = | 794.33 | nM | 6.10 |
| CHEMBL4562476 | — | Ki | = | 794.33 | nM | 6.10 |
| CHEMBL4473629 | — | Ki | = | 794.33 | nM | 6.10 |
| CHEMBL4443772 | — | Ki | = | 794.33 | nM | 6.10 |
| CHEMBL4436770 | — | Ki | = | 794.33 | nM | 6.10 |
| CHEMBL4566533 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL4453045 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL4520014 | — | Ki | = | 1258.93 | nM | 5.90 |
| CHEMBL4583339 | — | Ki | = | 1258.93 | nM | 5.90 |