Assay Detail
Binding
CHEMBL4351077
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Inhibition of PI3Kdelta (unknown origin)
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (CHEMBL3130) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Evolution of PI3Kγ and δ Inhibitors for Inflammatory and Autoimmune Diseases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 8.85 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4541570 | — | — | 1 | 10.00 |
| CHEMBL4470131 | — | — | 1 | 9.70 |
| CHEMBL4460140 | — | — | 1 | 9.22 |
| CHEMBL4558527 | AZD-8154 | 2.0 | 1 | 9.15 |
| CHEMBL4557936 | — | — | 1 | 9.15 |
| CHEMBL4101902 | — | — | 1 | 9.10 |
| CHEMBL4463183 | — | — | 1 | 9.00 |
| CHEMBL4516283 | — | — | 1 | 8.85 |
| CHEMBL3704701 | — | — | 1 | 8.72 |
| CHEMBL3959351 | — | — | 1 | 8.70 |
| CHEMBL4530831 | — | — | 1 | 8.70 |
| CHEMBL4444179 | — | — | 1 | 8.00 |
| CHEMBL4457478 | — | — | 1 | 7.96 |
| CHEMBL4297584 | TENALISIB | 2.0 | 1 | 7.60 |
| CHEMBL4543628 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4541570 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL4470131 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL4460140 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL4558527 | AZD-8154 | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL4557936 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL4101902 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL4463183 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4516283 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL3704701 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL3959351 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4530831 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4444179 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4457478 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL4297584 | TENALISIB | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL4543628 | — | IC50 | < | 10.0 | nM | - |