Compound Detail
CHEMBL4557936
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Basic Information
| ChEMBL ID | CHEMBL4557936 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | NKZNDGULUHLORP-ZDUSSCGKSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
391.5
MW (Da)
1.71
ALogP
9
HBA
3
HBD
120.7
PSA (Ų)
0.61
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 9.15
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform CHEMBL3130 | IC50 | 9.15 | 9.15 | 0.7 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform | IC50 | = | 0.7 | nM | 9.15 | Inhibition of PI3Kdelta (unknown origin) | 30582813 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 30582813 | 10.1021/acs.jmedchem.8b01298 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform | 1 |
Data from ChEMBL 36 via Core Engine