Assay Detail
Binding
CHEMBL4351101
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Vps34 (unknown origin)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Phosphatidylinositol 3-kinase catalytic subunit type 3 (CHEMBL1075165) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Evolution of PI3Kγ and δ Inhibitors for Inflammatory and Autoimmune Diseases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.34 | 6.01 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2216870 | IDELALISIB | 4.0 | 1 | 6.01 |
| CHEMBL4303323 | ACALISIB | 2.0 | 1 | 5.60 |
| CHEMBL3984425 | EGANELISIB | 2.0 | 1 | 4.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2216870 | IDELALISIB | IC50 | = | 980.0 | nM | 6.01 |
| CHEMBL4303323 | ACALISIB | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL3984425 | EGANELISIB | IC50 | = | 40000.0 | nM | 4.40 |