Assay Detail
Binding
CHEMBL4352202
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of RIP1 in mouse L929 cells assessed as reduction in TNF/zVAD.fmk-induced necrotic death measured after 24 hrs by cell titer-glo luminescent cell viability assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | L929 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Receptor-interacting serine/threonine-protein kinase 1 (CHEMBL3784911) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Discovery and Lead-Optimization of 4,5-Dihydropyrazoles as Mono-Kinase Selective, Orally Bioavailable and Efficacious Inhibitors of Receptor Interacting Protein 1 (RIP1) Kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.06 | 8.49 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4545939 | — | — | 1 | 8.49 |
| CHEMBL4514271 | — | — | 1 | 7.50 |
| CHEMBL4474320 | — | — | 1 | 5.20 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4545939 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL4514271 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL4474320 | — | IC50 | = | 6300.0 | nM | 5.20 |