Assay Detail
Binding
CHEMBL4352996
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Inhibition of p53 protein binding to MDM2 (unknown origin)
10
Total Activities
10
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
The past, present and future of potential small-molecule drugs targeting p53-MDM2/MDMX for cancer therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.35 | 9.10 |
| Ki | 3 | 7.77 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4463050 | — | — | 1 | 9.22 |
| CHEMBL4514512 | — | — | 1 | 9.10 |
| CHEMBL4539285 | — | — | 1 | 8.96 |
| CHEMBL4548050 | — | — | 1 | 8.92 |
| CHEMBL2177813 | — | — | 1 | 7.47 |
| CHEMBL2089208 | — | — | 1 | 7.05 |
| CHEMBL2089203 | — | — | 1 | 7.04 |
| CHEMBL2396744 | — | — | 1 | 6.31 |
| CHEMBL208562 | — | — | 1 | 6.15 |
| CHEMBL191334 | NUTLIN-3 | — | 1 | 4.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4463050 | — | Ki | = | 0.6 | nM | 9.22 |
| CHEMBL4514512 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL4539285 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL4548050 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL2177813 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL2089208 | — | Ki | = | 89.0 | nM | 7.05 |
| CHEMBL2089203 | — | Ki | = | 91.0 | nM | 7.04 |
| CHEMBL2396744 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL208562 | — | IC50 | = | 704.0 | nM | 6.15 |
| CHEMBL191334 | NUTLIN-3 | IC50 | = | 30000.0 | nM | 4.52 |