Assay Detail
Binding
CHEMBL4353048
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of thrombin (unknown origin) using Boc-Val-Pro-Arg-AMC as substrate preincubated with enzyme for 15 mins followed by addition of substrate by fluorescence plate reader analysis
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and structure-activity relationships of small-molecular di-basic esters, amides and carbamates as flaviviral protease inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.73 | 6.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4561509 | — | — | 1 | 6.28 |
| CHEMBL590799 | CAMOSTAT | 3.0 | 1 | 6.11 |
| CHEMBL4451902 | — | — | 1 | 6.10 |
| CHEMBL3344303 | — | — | 1 | 5.39 |
| CHEMBL4586045 | — | — | 1 | 4.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4561509 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL590799 | CAMOSTAT | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL4451902 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL3344303 | — | IC50 | = | 4080.0 | nM | 5.39 |
| CHEMBL4586045 | — | IC50 | = | 17600.0 | nM | 4.75 |