Assay Detail
Binding
CHEMBL4353356
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H] prazosin from human cloned adrenoceptor alpha 1B expressed in CHO cell membrane incubated for 30 mins by liquid scintillation counter
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
1,3-Dioxane as a scaffold for potent and selective 5-HT1AR agonist with in-vivo anxiolytic, anti-depressant and anti-nociceptive activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 21 | 7.09 | 7.83 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4458714 | — | — | 1 | 7.83 |
| CHEMBL4467585 | — | — | 1 | 7.80 |
| CHEMBL4462600 | — | — | 1 | 7.60 |
| CHEMBL4570387 | — | — | 1 | 7.56 |
| CHEMBL4551941 | — | — | 1 | 7.51 |
| CHEMBL4588223 | — | — | 1 | 7.50 |
| CHEMBL4526865 | — | — | 1 | 7.43 |
| CHEMBL286003 | — | — | 1 | 7.33 |
| CHEMBL4582160 | — | — | 1 | 7.25 |
| CHEMBL37883 | — | — | 1 | 7.20 |
| CHEMBL4579802 | — | — | 1 | 7.19 |
| CHEMBL31354 | WAY-100,635 | — | 1 | 7.18 |
| CHEMBL4439658 | — | — | 1 | 7.04 |
| CHEMBL4520390 | — | — | 1 | 7.02 |
| CHEMBL4462768 | — | — | 1 | 6.99 |
| CHEMBL4457585 | — | — | 1 | 6.99 |
| CHEMBL4473623 | — | — | 1 | 6.97 |
| CHEMBL4580335 | — | — | 1 | 6.78 |
| CHEMBL4544457 | — | — | 1 | 6.55 |
| CHEMBL4558985 | — | — | 1 | 5.64 |
| CHEMBL4468507 | — | — | 1 | 5.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4458714 | — | Ki | = | 14.79 | nM | 7.83 |
| CHEMBL4467585 | — | Ki | = | 15.85 | nM | 7.80 |
| CHEMBL4462600 | — | Ki | = | 25.12 | nM | 7.60 |
| CHEMBL4570387 | — | Ki | = | 27.54 | nM | 7.56 |
| CHEMBL4551941 | — | Ki | = | 30.9 | nM | 7.51 |
| CHEMBL4588223 | — | Ki | = | 31.62 | nM | 7.50 |
| CHEMBL4526865 | — | Ki | = | 37.15 | nM | 7.43 |
| CHEMBL286003 | — | Ki | = | 46.77 | nM | 7.33 |
| CHEMBL4582160 | — | Ki | = | 56.23 | nM | 7.25 |
| CHEMBL37883 | — | Ki | = | 63.1 | nM | 7.20 |
| CHEMBL4579802 | — | Ki | = | 64.57 | nM | 7.19 |
| CHEMBL31354 | WAY-100,635 | Ki | = | 66.07 | nM | 7.18 |
| CHEMBL4439658 | — | Ki | = | 91.2 | nM | 7.04 |
| CHEMBL4520390 | — | Ki | = | 95.5 | nM | 7.02 |
| CHEMBL4462768 | — | Ki | = | 102.33 | nM | 6.99 |
| CHEMBL4457585 | — | Ki | = | 102.33 | nM | 6.99 |
| CHEMBL4473623 | — | Ki | = | 107.15 | nM | 6.97 |
| CHEMBL4580335 | — | Ki | = | 165.96 | nM | 6.78 |
| CHEMBL4544457 | — | Ki | = | 281.84 | nM | 6.55 |
| CHEMBL4558985 | — | Ki | = | 2290.87 | nM | 5.64 |
| CHEMBL4468507 | — | Ki | = | 3019.95 | nM | 5.52 |