Assay Detail
Functional
CHEMBL4353407
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Cytotoxicity against human HCT116 cells assessed as decrease in cell viability
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Triptolide: Medicinal chemistry, chemical biology and clinical progress.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.97 | 8.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL463763 | TRIPTOLIDE | 3.0 | 1 | 8.33 |
| CHEMBL4580174 | — | — | 1 | 8.08 |
| CHEMBL4538993 | — | — | 1 | 7.15 |
| CHEMBL4446222 | — | — | 1 | 7.13 |
| CHEMBL4522101 | — | — | 1 | 6.45 |
| CHEMBL4454789 | — | — | 1 | 6.27 |
| CHEMBL4440604 | — | — | 1 | 6.25 |
| CHEMBL4588051 | — | — | 1 | 6.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL463763 | TRIPTOLIDE | IC50 | = | 4.7 | nM | 8.33 |
| CHEMBL4580174 | — | IC50 | = | 8.4 | nM | 8.08 |
| CHEMBL4538993 | — | IC50 | = | 70.7 | nM | 7.15 |
| CHEMBL4446222 | — | IC50 | = | 74.7 | nM | 7.13 |
| CHEMBL4522101 | — | IC50 | = | 354.0 | nM | 6.45 |
| CHEMBL4454789 | — | IC50 | = | 537.0 | nM | 6.27 |
| CHEMBL4440604 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL4588051 | — | IC50 | = | 772.0 | nM | 6.11 |