Assay Detail
Binding
CHEMBL4353483
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Inhibition of MDM2 (unknown origin)
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Development of selective small molecule MDM2 degraders based on nutlin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 8.72 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3125702 | NAVTEMADLIN | 3.0 | 1 | 9.22 |
| CHEMBL2402737 | IDASANUTLIN | 3.0 | 1 | 8.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3125702 | NAVTEMADLIN | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL2402737 | IDASANUTLIN | IC50 | = | 6.0 | nM | 8.22 |