Assay Detail
Binding
CHEMBL4353731
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to KDM5B (unknown origin)
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
C8-substituted pyrido[3,4-d]pyrimidin-4(3H)-ones: Studies towards the identification of potent, cell penetrant Jumonji C domain containing histone lysine demethylase 4 subfamily (KDM4) inhibitors, compound profiling in cell-based target engagement assays.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 8.53 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4567766 | — | — | 1 | 9.00 |
| CHEMBL4438830 | — | — | 1 | 9.00 |
| CHEMBL3774537 | — | — | 1 | 8.70 |
| CHEMBL4573390 | — | — | 1 | 8.70 |
| CHEMBL4447515 | — | — | 1 | 8.52 |
| CHEMBL4585876 | — | — | 1 | 8.40 |
| CHEMBL4449500 | — | — | 1 | 8.15 |
| CHEMBL4525269 | — | — | 1 | 7.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4567766 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL4438830 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL3774537 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL4573390 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL4447515 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL4585876 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL4449500 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL4525269 | — | Ki | = | 16.0 | nM | 7.80 |