Assay Detail
Binding
CHEMBL4354193
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Inhibition of CDK2/cyclin A2 (unknown origin) using histone H1 and ATP as substrate incubated for 40 mins by kinase-glo luminescence assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Discovery of novel pyrimidine-based benzothiazole derivatives as potent cyclin-dependent kinase 2 inhibitors with anticancer activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 7.66 | 7.90 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4526687 | — | — | 1 | 7.90 |
| CHEMBL4454288 | — | — | 1 | 7.81 |
| CHEMBL4435968 | — | — | 1 | 7.78 |
| CHEMBL4528300 | — | — | 1 | 7.67 |
| CHEMBL4475342 | — | — | 1 | 7.66 |
| CHEMBL4543030 | — | — | 1 | 7.42 |
| CHEMBL488436 | AZD-5438 | 1.0 | 1 | 7.35 |
| CHEMBL4539730 | — | — | 1 | - |
| CHEMBL4470088 | — | — | 1 | - |
| CHEMBL4527631 | — | — | 1 | - |
| CHEMBL4543207 | — | — | 1 | - |
| CHEMBL4552048 | — | — | 1 | - |
| CHEMBL4459752 | — | — | 1 | - |
| CHEMBL4468668 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4526687 | — | IC50 | = | 12.7 | nM | 7.90 |
| CHEMBL4454288 | — | IC50 | = | 15.4 | nM | 7.81 |
| CHEMBL4435968 | — | IC50 | = | 16.5 | nM | 7.78 |
| CHEMBL4528300 | — | IC50 | = | 21.4 | nM | 7.67 |
| CHEMBL4475342 | — | IC50 | = | 21.7 | nM | 7.66 |
| CHEMBL4543030 | — | IC50 | = | 37.8 | nM | 7.42 |
| CHEMBL488436 | AZD-5438 | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL4539730 | — | IC50 | - | — | - | |
| CHEMBL4470088 | — | IC50 | - | — | - | |
| CHEMBL4527631 | — | IC50 | - | — | - | |
| CHEMBL4543207 | — | IC50 | - | — | - | |
| CHEMBL4552048 | — | IC50 | - | — | - | |
| CHEMBL4459752 | — | IC50 | - | — | - | |
| CHEMBL4468668 | — | IC50 | - | — | - |