Assay Detail

CHEMBL4355050

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Functional

Antiviral activity against HIV1 NL4-3 infected human TZM-bl cells assessed as reduction in viral replication

ChEMBL ↗

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Target

Human immunodeficiency virus 1 (CHEMBL378) ↗

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Human immunodeficiency virus 1 (CHEMBL378) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Human immunodeficiency virus 1

CHEMBL378

Anchored from Assay target.

Protein identity Human immunodeficiency virus 1

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Human immunodeficiency virus 1
Confidence	1 — Organism
Curated By	Autocuration

Target

Human immunodeficiency virus 1 (CHEMBL378) ↗

Type	ORGANISM
Organism	Human immunodeficiency virus 1

Publication

Synthetic small-molecule RNA ligands: future prospects as therapeutic agents.

Di Giorgio A, Duca M.
Medchemcomm (2019) 10 : 1242 -1255
PubMed 31534649 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	4.64	4.64

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL1572	NETILMICIN	4.0	1	4.64

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL1572	NETILMICIN	IC50	=	23100.0	nM	4.64