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Assay Detail

CHEMBL4355154

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiproliferative activity against human HL60 cells assessed as reduction in cell viability after 3 days by trypan blue dye based hemocytometer counting method
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type HL-60
Confidence 1 — Organism
Curated By Autocuration

Target

HL-60 (CHEMBL383)
Type CELL-LINE
Organism Homo sapiens

Publication

Potential Anticancer Agents Characterized from Selected Tropical Plants.
Ren Y, de Blanco EJC, Fuchs JR, Soejarto DD, Burdette JE, Swanson SM, Kinghorn AD.
J Nat Prod (2019) 82 : 657 -679
PubMed 30830783 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 2 6.43 6.77

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL555017 GAMBOGIC ACID 1 6.77
CHEMBL4465384 1 6.08

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL555017 GAMBOGIC ACID IC50 = 170.0 nM 6.77
CHEMBL4465384 IC50 = 830.0 nM 6.08