Assay Detail
Binding
CHEMBL4355296
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Inhibition of Plasmodium falciparum plasmepsin 2 using fluorescently labeled peptide substrate by fluorescence method
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Plasmodium falciparum |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Exploiting Structural Dynamics To Design Open-Flap Inhibitors of Malarial Aspartic Proteases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 6.38 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4456145 | — | — | 1 | 7.52 |
| CHEMBL4585628 | — | — | 1 | 7.30 |
| CHEMBL4578117 | — | — | 1 | 7.16 |
| CHEMBL4541926 | — | — | 1 | 6.89 |
| CHEMBL4552145 | — | — | 1 | 6.82 |
| CHEMBL4457677 | — | — | 1 | 6.77 |
| CHEMBL4436986 | — | — | 1 | 6.72 |
| CHEMBL4553173 | — | — | 1 | 6.46 |
| CHEMBL4456617 | — | — | 1 | 6.42 |
| CHEMBL4472299 | — | — | 1 | 6.17 |
| CHEMBL4554580 | — | — | 1 | 5.71 |
| CHEMBL4590673 | — | — | 1 | 5.38 |
| CHEMBL4581864 | — | — | 1 | 5.30 |
| CHEMBL4558605 | — | — | 1 | 4.72 |
| CHEMBL4442042 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4456145 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL4585628 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL4578117 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL4541926 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL4552145 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL4457677 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL4436986 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL4553173 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL4456617 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL4472299 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL4554580 | — | IC50 | = | 1950.0 | nM | 5.71 |
| CHEMBL4590673 | — | IC50 | = | 4190.0 | nM | 5.38 |
| CHEMBL4581864 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL4558605 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL4442042 | — | IC50 | <= | 45.0 | nM | - |