Assay Detail
Binding
CHEMBL4355755
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of OGA in rat PC12 cells assessed as OGlcNAcylated protein level incubated for 24 hrs by ELISA
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of MK-8719, a Potent O-GlcNAcase Inhibitor as a Potential Treatment for Tauopathies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 25 | 7.00 | 8.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4443587 | — | — | 1 | 8.77 |
| CHEMBL4444446 | — | — | 1 | 7.97 |
| CHEMBL1213603 | — | — | 1 | 7.87 |
| CHEMBL4545886 | — | — | 1 | 7.55 |
| CHEMBL4113501 | — | — | 1 | 7.51 |
| CHEMBL4516713 | — | — | 1 | 7.48 |
| CHEMBL4108795 | — | — | 1 | 7.46 |
| CHEMBL4483089 | — | — | 1 | 7.43 |
| CHEMBL4561925 | — | — | 1 | 7.38 |
| CHEMBL4111094 | — | — | 1 | 7.28 |
| CHEMBL3897809 | — | — | 1 | 7.24 |
| CHEMBL4586062 | — | — | 1 | 6.92 |
| CHEMBL3681909 | — | — | 1 | 6.82 |
| CHEMBL3686728 | — | — | 1 | 6.78 |
| CHEMBL4543991 | — | — | 1 | 6.75 |
| CHEMBL4473252 | — | — | 1 | 6.75 |
| CHEMBL4454814 | — | — | 1 | 6.65 |
| CHEMBL4112447 | — | — | 1 | 6.51 |
| CHEMBL4476839 | — | — | 1 | 6.48 |
| CHEMBL4110365 | — | — | 1 | 6.45 |
| CHEMBL4107048 | — | — | 1 | 6.44 |
| CHEMBL4448352 | — | — | 1 | 6.35 |
| CHEMBL4583010 | — | — | 1 | 6.35 |
| CHEMBL4456515 | — | — | 1 | 6.29 |
| CHEMBL4513613 | — | — | 1 | 5.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4443587 | — | EC50 | = | 1.71 | nM | 8.77 |
| CHEMBL4444446 | — | EC50 | = | 10.6 | nM | 7.97 |
| CHEMBL1213603 | — | EC50 | = | 13.5 | nM | 7.87 |
| CHEMBL4545886 | — | EC50 | = | 28.0 | nM | 7.55 |
| CHEMBL4113501 | — | EC50 | = | 31.2 | nM | 7.51 |
| CHEMBL4516713 | — | EC50 | = | 33.1 | nM | 7.48 |
| CHEMBL4108795 | — | EC50 | = | 34.4 | nM | 7.46 |
| CHEMBL4483089 | — | EC50 | = | 36.7 | nM | 7.43 |
| CHEMBL4561925 | — | EC50 | = | 41.4 | nM | 7.38 |
| CHEMBL4111094 | — | EC50 | = | 52.7 | nM | 7.28 |
| CHEMBL3897809 | — | EC50 | = | 58.2 | nM | 7.24 |
| CHEMBL4586062 | — | EC50 | = | 119.0 | nM | 6.92 |
| CHEMBL3681909 | — | EC50 | = | 152.0 | nM | 6.82 |
| CHEMBL3686728 | — | EC50 | = | 165.0 | nM | 6.78 |
| CHEMBL4543991 | — | EC50 | = | 176.0 | nM | 6.75 |
| CHEMBL4473252 | — | EC50 | = | 177.0 | nM | 6.75 |
| CHEMBL4454814 | — | EC50 | = | 224.0 | nM | 6.65 |
| CHEMBL4112447 | — | EC50 | = | 307.0 | nM | 6.51 |
| CHEMBL4476839 | — | EC50 | = | 328.0 | nM | 6.48 |
| CHEMBL4110365 | — | EC50 | = | 358.0 | nM | 6.45 |
| CHEMBL4107048 | — | EC50 | = | 364.0 | nM | 6.44 |
| CHEMBL4448352 | — | EC50 | = | 443.0 | nM | 6.35 |
| CHEMBL4583010 | — | EC50 | = | 445.0 | nM | 6.35 |
| CHEMBL4456515 | — | EC50 | = | 509.0 | nM | 6.29 |
| CHEMBL4513613 | — | EC50 | = | 2400.0 | nM | 5.62 |