Assay Detail
Functional
CHEMBL4356342
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Anti-fibrinolytic activity in human whole blood assessed as reduction in clot lysis incubated for 5 mins in presence of tissue-type plasminogen activator by rotational thromboelastometry
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Tissue | Blood |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Fibrinolysis Inhibitors: Potential Drugs for the Treatment and Prevention of Bleeding.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.19 | 6.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4471466 | — | — | 1 | 6.82 |
| CHEMBL877 | TRANEXAMIC ACID | 4.0 | 1 | 5.56 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4471466 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL877 | TRANEXAMIC ACID | IC50 | = | 2750.0 | nM | 5.56 |