Assay Detail
Binding
CHEMBL4356419
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of CSN5 (unknown origin) using fluorescence-labeled CRL substrate by TR-FRET assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
COP9 signalosome complex subunit 5 (CHEMBL4105809) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Advances in Discovering Deubiquitinating Enzyme (DUB) Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.73 | 8.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4528101 | — | — | 1 | 8.24 |
| CHEMBL4447716 | — | — | 1 | 7.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4528101 | — | IC50 | = | 5.8 | nM | 8.24 |
| CHEMBL4447716 | — | IC50 | = | 60.0 | nM | 7.22 |