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Assay Detail

CHEMBL4356534

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of mouse ABHD6 expressed in HEK293 cells using 2-AG as substrate
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Mus musculus
Cell Type HEK293
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Monoacylglycerol lipase ABHD6 (CHEMBL5010)
Type SINGLE PROTEIN
Organism Mus musculus

Publication

Benzisothiazolinone Derivatives as Potent Allosteric Monoacylglycerol Lipase Inhibitors That Functionally Mimic Sulfenylation of Regulatory Cysteines.
Castelli R, Scalvini L, Vacondio F, Lodola A, Anselmi M, Vezzosi S, Carmi C, Bassi M, Ferlenghi F, Rivara S, Møller IR, Rand KD, Daglian J, Wei D, Dotsey EY, Ahmed F, Jung KM, Stella N, Singh S, Mor M, Piomelli D.
J Med Chem (2020) 63 : 1261 -1280
PubMed 31714779 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 5.45 5.45

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2391916 1 5.45

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2391916 IC50 = 3580.0 nM 5.45