Assay Detail
Binding
CHEMBL4356730
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to recombinant human His/SUMO-tagged STAT3 (127 to 688 residues) expressed in Escherichia coli Rosetta (DE3) incubated for 1 hr by fluorescence polarization assay
10
Total Activities
10
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Signal transducer and activator of transcription 3 (CHEMBL4026) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Structure-Based Discovery of SD-36 as a Potent, Selective, and Efficacious PROTAC Degrader of STAT3 Protein.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 7.52 | 8.15 |
| Kd | 1 | 7.36 | 7.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4560429 | — | — | 1 | 8.15 |
| CHEMBL4471887 | — | — | 1 | 7.92 |
| CHEMBL4575382 | — | — | 1 | 7.85 |
| CHEMBL4443339 | — | — | 1 | 7.85 |
| CHEMBL4515406 | — | — | 1 | 7.85 |
| CHEMBL4571181 | — | — | 1 | 7.60 |
| CHEMBL4443240 | — | — | 1 | 7.48 |
| CHEMBL4452527 | — | — | 1 | 7.36 |
| CHEMBL4538737 | — | — | 1 | 6.79 |
| CHEMBL4567312 | — | — | 1 | 6.23 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4560429 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL4471887 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL4575382 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL4443339 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL4515406 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL4571181 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL4443240 | — | Ki | = | 33.0 | nM | 7.48 |
| CHEMBL4452527 | — | Kd | = | 44.0 | nM | 7.36 |
| CHEMBL4538737 | — | Ki | = | 164.0 | nM | 6.79 |
| CHEMBL4567312 | — | Ki | = | 584.0 | nM | 6.23 |