Assay Detail
Binding
CHEMBL4357416
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Inhibition of human activated factor XI using pyro-Glu-Pro-Arg-pNA as substrate by incubated at 25 degreeC spectrophotometry
4
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Potent, Orally Bioavailable, and Efficacious Macrocyclic Inhibitors of Factor XIa. Discovery of Pyridine-Based Macrocycles Possessing Phenylazole Carboxamide P1 Groups.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 6.24 | 7.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4554665 | — | — | 1 | 7.33 |
| CHEMBL4522419 | — | — | 2 | 5.86 |
| CHEMBL4442549 | — | — | 1 | 5.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4554665 | — | Ki | = | 47.0 | nM | 7.33 |
| CHEMBL4522419 | — | Ki | = | 1390.0 | nM | 5.86 |
| CHEMBL4442549 | — | Ki | = | 2890.0 | nM | 5.54 |
| CHEMBL4522419 | — | Ki | > | 13000.0 | nM | - |