Assay Detail
Binding
CHEMBL4357706
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human His-tagged FGFR1 (308 to 731 residues) expressed in baculovirus expression system using tyrosine-4 peptide as substrate incubated for 1 hr by Z'-LYTE assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-Based Design of a Potent and Selective Covalent Inhibitor for SRC Kinase That Targets a P-Loop Cysteine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 6.74 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4538743 | — | — | 1 | 7.92 |
| CHEMBL4574265 | — | — | 1 | 7.77 |
| CHEMBL4563120 | — | — | 1 | 7.70 |
| CHEMBL3883384 | — | — | 1 | 7.27 |
| CHEMBL4562024 | — | — | 1 | 7.14 |
| CHEMBL4442889 | — | — | 1 | 7.05 |
| CHEMBL4460150 | — | — | 1 | 6.92 |
| CHEMBL4462060 | — | — | 1 | 6.43 |
| CHEMBL4528820 | — | — | 1 | 6.41 |
| CHEMBL4569421 | — | — | 1 | 5.98 |
| CHEMBL4475369 | — | — | 1 | 5.17 |
| CHEMBL4515441 | — | — | 1 | 5.08 |
| CHEMBL4436957 | — | — | 1 | - |
| CHEMBL4453645 | — | — | 1 | - |
| CHEMBL4442593 | — | — | 1 | - |
| CHEMBL4561015 | — | — | 1 | - |
| CHEMBL4592277 | — | — | 1 | - |
| CHEMBL4443649 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4538743 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4574265 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL4563120 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL3883384 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL4562024 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL4442889 | — | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL4460150 | — | IC50 | = | 119.0 | nM | 6.92 |
| CHEMBL4462060 | — | IC50 | = | 373.0 | nM | 6.43 |
| CHEMBL4528820 | — | IC50 | = | 391.0 | nM | 6.41 |
| CHEMBL4569421 | — | IC50 | = | 1050.0 | nM | 5.98 |
| CHEMBL4475369 | — | IC50 | = | 6710.0 | nM | 5.17 |
| CHEMBL4515441 | — | IC50 | = | 8340.0 | nM | 5.08 |
| CHEMBL4436957 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4453645 | — | IC50 | > | 3330.0 | nM | - |
| CHEMBL4442593 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4561015 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4592277 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4443649 | — | IC50 | > | 10000.0 | nM | - |