Assay Detail
Binding
CHEMBL4358377
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125I]Ang II from AT1 receptor in rat liver membranes
3
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Liver |
| Subcellular | Membranes |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Type-1 angiotensin II receptor A (CHEMBL329) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
The Other Angiotensin II Receptor: AT2R as a Therapeutic Target.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 8.41 | 8.41 |
| IC50 | 1 | 8.85 | 8.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL290214 | — | — | 1 | 8.85 |
| CHEMBL288174 | — | — | 1 | 8.41 |
| CHEMBL189568 | BULOXIBUTID | 0.5 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL290214 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL288174 | — | Ki | = | 3.9 | nM | 8.41 |
| CHEMBL189568 | BULOXIBUTID | Ki | > | 10000.0 | nM | - |