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Evidence Snapshot

Type-1 angiotensin II receptor A

CHEMBL329 SINGLE PROTEIN Rattus norvegicus
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-13T22:30:50Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL329
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Type-1 angiotensin II receptor A as ChEMBL target CHEMBL329, mapped to UniProt P25095. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Type-1 angiotensin II receptor A
SINGLE PROTEIN · Rattus norvegicus
As of 2026-09-13
ChEMBL target ID
CHEMBL329
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
P25095
Type-1 angiotensin II receptor A
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Review-ready Target Rationale

Why Type-1 angiotensin II receptor A matters

As of 2026-09-13

Type-1 angiotensin II receptor A is reviewed as Type-1 angiotensin II receptor A (UniProt P25095); the current evidence base includes 10 approved drugs, 267 compounds, and 30 assays, with lead potency reaching pChEMBL 9.6.

Disease context
Disease signal

Disease relevance is not yet populated for this evidence card.

This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

ChEMBL target record
Activity base
Portfolio and assay base

ChEMBL currently tracks 10 approved drugs, 267 compounds, and 30 assays for this target. The dominant activity type is EC50. CHEMBL1017 is the current potency anchor at pChEMBL 9.6.

Use CHEMBL1017 as the tractability anchor when discussing potency (pChEMBL 9.6).

Activity source · ChEMBL 36 via Core Engine
10 approved pChEMBL 9.6
Source Guidance

Start with the right source

Pick the first block or linked source that matches the review question in front of you.

Need the shortest review narrative first?
Review-ready Target Rationale
One-page rationale with as-of-date and attribution

Start with the review rationale when you need to explain why Type-1 angiotensin II receptor A matters before drilling into raw source blocks.

Jump to Review Rationale
Need stable protein naming or accession mapping?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Go back to the target snapshot when you need the naming and mapping contract behind UniProt P25095, not just the summarized rationale.

Open Protein Context
Need disease fit or evidence level for program framing?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use the target snapshot disease block when you need the disease program and supporting signals, not only the card summary.

Open Disease Context

Snapshot State

No project snapshot selected. Export uses the live evidence card state.

267
Total Compounds
30
Total Assays
10
Approved Drugs
IC50: 54.0, KI: 117.0, EC50: 161.0, KD: 26.0
Activity Types

pChEMBL Activity Distribution

Top 5 Inhibitors (by pChEMBL)

Structure Compound pChEMBL Type Phase
No preferred name
CHEMBL1017
 9.6 Ki Approved
No preferred name
CHEMBL121
 9.6 Ki Approved
No preferred name
CHEMBL408403
 9.4 IC50 Approved
No preferred name
CHEMBL7550
 9.4 IC50 —
No preferred name
CHEMBL7550
 9.3 Ki —

Approved Drugs

Structure Compound First Approval
ANGIOTENSIN II
CHEMBL408403
 2017
ROSIGLITAZONE
CHEMBL121
 1999
TELMISARTAN
CHEMBL1017
 1998
IRBESARTAN
CHEMBL1513
 1997
VALSARTAN
CHEMBL1069
 1996
LOSARTAN
CHEMBL191
 1995
SARALASIN
CHEMBL938
 1982
← Target Page
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-13T22:30:50Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL329