Assay Detail
Binding
CHEMBL4358388
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at rat IP3R1 expressed in human HEK cells assessed as increase in calcium release by Mag-fluo4 dye based assay
8
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1 (CHEMBL2804) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
d-chiro-Inositol Ribophostin: A Highly Potent Agonist of d-myo-Inositol 1,4,5-Trisphosphate Receptors: Synthesis and Biological Activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 7.09 | 7.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4578747 | — | — | 2 | 7.57 |
| CHEMBL4483666 | — | — | 2 | 7.28 |
| CHEMBL204385 | ADENOPHOSTIN A | — | 2 | 6.81 |
| CHEMBL279107 | INS(1,4,5)P3 | — | 2 | 6.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4578747 | — | EC50 | = | 27.0 | nM | 7.57 |
| CHEMBL4578747 | — | EC50 | = | 26.92 | nM | 7.57 |
| CHEMBL4483666 | — | EC50 | = | 52.0 | nM | 7.28 |
| CHEMBL4483666 | — | EC50 | = | 52.48 | nM | 7.28 |
| CHEMBL204385 | ADENOPHOSTIN A | EC50 | = | 155.0 | nM | 6.81 |
| CHEMBL204385 | ADENOPHOSTIN A | EC50 | = | 154.88 | nM | 6.81 |
| CHEMBL279107 | INS(1,4,5)P3 | EC50 | = | 209.0 | nM | 6.68 |
| CHEMBL279107 | INS(1,4,5)P3 | EC50 | = | 208.93 | nM | 6.68 |