Assay Detail
Functional
CHEMBL4358400
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human HCT116 cells harboring PIK3CA mutant assessed as reduction in cell viability measured after 72 hrs by CCK8 assay
41
Total Activities
41
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, Synthesis, and Biological Evaluation of Imidazo[1,2-a]pyridine Derivatives as Novel PI3K/mTOR Dual Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 41 | 6.37 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4440406 | — | — | 1 | 8.00 |
| CHEMBL4439080 | — | — | 1 | 7.52 |
| CHEMBL4532851 | — | — | 1 | 7.40 |
| CHEMBL4563247 | — | — | 1 | 7.16 |
| CHEMBL4437362 | — | — | 1 | 7.10 |
| CHEMBL4574827 | — | — | 1 | 7.10 |
| CHEMBL4446838 | — | — | 1 | 6.96 |
| CHEMBL3218576 | COPANLISIB | 4.0 | 1 | 6.92 |
| CHEMBL4456700 | — | — | 1 | 6.89 |
| CHEMBL4522254 | — | — | 1 | 6.89 |
| CHEMBL4519095 | — | — | 1 | 6.85 |
| CHEMBL4531493 | — | — | 1 | 6.70 |
| CHEMBL1765463 | — | — | 1 | 6.60 |
| CHEMBL4470122 | — | — | 1 | 6.58 |
| CHEMBL4578885 | — | — | 1 | 6.55 |
| CHEMBL4213353 | — | — | 1 | 6.47 |
| CHEMBL4580837 | — | — | 1 | 6.47 |
| CHEMBL4536505 | — | — | 1 | 6.43 |
| CHEMBL4454774 | — | — | 1 | 6.36 |
| CHEMBL4462621 | — | — | 1 | 6.33 |
| CHEMBL4449613 | — | — | 1 | 6.31 |
| CHEMBL4516974 | — | — | 1 | 6.31 |
| CHEMBL4455270 | — | — | 1 | 6.30 |
| CHEMBL4516163 | — | — | 1 | 5.80 |
| CHEMBL4534475 | — | — | 1 | 5.67 |
| CHEMBL4537128 | — | — | 1 | 5.65 |
| CHEMBL4455710 | — | — | 1 | 5.63 |
| CHEMBL4473826 | — | — | 1 | 5.62 |
| CHEMBL4462032 | — | — | 1 | 5.45 |
| CHEMBL4461136 | — | — | 1 | 5.23 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4440406 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4439080 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL4532851 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL4563247 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL4437362 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL4574827 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL4446838 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL3218576 | COPANLISIB | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL4456700 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL4522254 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL4519095 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL4531493 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL1765463 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL4470122 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL4578885 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL4213353 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL4580837 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL4536505 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL4454774 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL4462621 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL4449613 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL4516974 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL4455270 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL4516163 | — | IC50 | = | 1590.0 | nM | 5.80 |
| CHEMBL4534475 | — | IC50 | = | 2130.0 | nM | 5.67 |
| CHEMBL4537128 | — | IC50 | = | 2220.0 | nM | 5.65 |
| CHEMBL4455710 | — | IC50 | = | 2320.0 | nM | 5.63 |
| CHEMBL4473826 | — | IC50 | = | 2380.0 | nM | 5.62 |
| CHEMBL4462032 | — | IC50 | = | 3540.0 | nM | 5.45 |
| CHEMBL4461136 | — | IC50 | = | 5840.0 | nM | 5.23 |
| CHEMBL4475217 | — | IC50 | = | 5950.0 | nM | 5.22 |
| CHEMBL4444638 | — | IC50 | = | 13400.0 | nM | 4.87 |
| CHEMBL4441605 | — | IC50 | = | 15900.0 | nM | 4.80 |
| CHEMBL4476850 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4448324 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4529551 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4577573 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4466554 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4457705 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4568909 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4555870 | — | IC50 | > | 10000.0 | nM | - |