Assay Detail

CHEMBL4358929

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ADMET

Inhibition of human Cathepsin L using Cbz-Phe-Arg-AMC as substrate by fluorescence assay

ChEMBL ↗

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Target

Procathepsin L (CHEMBL3837) ↗

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Primary target Procathepsin L

CHEMBL3837

Anchored from Assay target.

Protein identity Procathepsin L

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	ADMET
Organism	Homo sapiens
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

Procathepsin L (CHEMBL3837) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

Peptidomimetic Vinyl Heterocyclic Inhibitors of Cruzain Effect Antitrypanosomal Activity.

Chenna BC, Li L, Mellott DM, Zhai X, Siqueira-Neto JL, Calvet Alvarez C, Bernatchez JA, Desormeaux E, Alvarez Hernandez E, Gomez J, McKerrow JH, Cruz-Reyes J, Meek TD.
J Med Chem (2020) 63 : 3298 -3316
PubMed 32125159 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	9.70	9.70

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL91704	K-777	2.0	1	9.70

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL91704	K-777	IC50	=	0.2	nM	9.70