Assay Detail
Binding
CHEMBL4359339
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human EGFR L858R/T790M/C797S mutant using poly[Glu:Tyr] (4:1) as substrate measured in presence of [gamma-33P]ATP by radiometric assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structural Basis for EGFR Mutant Inhibition by Trisubstituted Imidazole Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.05 | 7.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4098072 | — | — | 1 | 7.05 |
| CHEMBL4441037 | — | — | 1 | - |
| CHEMBL4575583 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4098072 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL4441037 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4575583 | — | IC50 | > | 5000.0 | nM | - |