Assay Detail
Binding
CHEMBL4359594
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of Alexa Fluor 647-labeled ligand from BRD4 BD2 (unknown origin) measured after 30 mins by TR-FRET assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Optimization of Potent ATAD2 and CECR2 Bromodomain Inhibitors with an Atypical Binding Mode.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.07 | 5.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4465880 | — | — | 1 | 5.30 |
| CHEMBL4577486 | — | — | 1 | 5.00 |
| CHEMBL4449894 | — | — | 1 | 4.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4465880 | — | IC50 | = | 5011.87 | nM | 5.30 |
| CHEMBL4577486 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL4449894 | — | IC50 | = | 12589.25 | nM | 4.90 |