Assay Detail
Binding
CHEMBL4359602
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to human partial length CECR2 (P423 to D543 residues) expressed in bacterial expression system by BROMOscan assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Chromatin remodeling regulator CECR2 (CHEMBL3108639) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Optimization of Potent ATAD2 and CECR2 Bromodomain Inhibitors with an Atypical Binding Mode.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 3 | 7.90 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4577486 | — | — | 1 | 8.10 |
| CHEMBL4465880 | — | — | 1 | 8.00 |
| CHEMBL4449894 | — | — | 1 | 7.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4577486 | — | Kd | = | 7.943 | nM | 8.10 |
| CHEMBL4465880 | — | Kd | = | 10.0 | nM | 8.00 |
| CHEMBL4449894 | — | Kd | = | 25.12 | nM | 7.60 |