Assay Detail
Binding
CHEMBL4359603
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Binding affinity to human partial length GCN5L2 (E726 to K837 residues) expressed in bacterial expression system by BROMOscan assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Optimization of Potent ATAD2 and CECR2 Bromodomain Inhibitors with an Atypical Binding Mode.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 3 | 6.57 | 6.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4465880 | — | — | 1 | 6.80 |
| CHEMBL4449894 | — | — | 1 | 6.60 |
| CHEMBL4577486 | — | — | 1 | 6.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4465880 | — | Kd | = | 158.49 | nM | 6.80 |
| CHEMBL4449894 | — | Kd | = | 251.19 | nM | 6.60 |
| CHEMBL4577486 | — | Kd | = | 501.19 | nM | 6.30 |