Assay Detail
Binding
CHEMBL4359604
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to human partial length TAF1 bromodomain 2 (D1521 to D1656 residues) expressed in bacterial expression system by BROMOscan assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Transcription initiation factor TFIID subunit 1 (CHEMBL3217390) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Optimization of Potent ATAD2 and CECR2 Bromodomain Inhibitors with an Atypical Binding Mode.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 3 | 7.23 | 7.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4449894 | — | — | 1 | 7.80 |
| CHEMBL4465880 | — | — | 1 | 7.20 |
| CHEMBL4577486 | — | — | 1 | 6.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4449894 | — | Kd | = | 15.85 | nM | 7.80 |
| CHEMBL4465880 | — | Kd | = | 63.1 | nM | 7.20 |
| CHEMBL4577486 | — | Kd | = | 199.53 | nM | 6.70 |