Assay Detail
Binding
CHEMBL4359614
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of BSP-BODIPY binding to Nanoluc-tagged CECR2 (unknown origin) expressed in HEK293 cells measured after 4 to 6 hrs by NanoBRET assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Chromatin remodeling regulator CECR2 (CHEMBL3108639) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Optimization of Potent ATAD2 and CECR2 Bromodomain Inhibitors with an Atypical Binding Mode.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.10 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4465880 | — | — | 1 | 7.40 |
| CHEMBL4577486 | — | — | 1 | 7.30 |
| CHEMBL4449894 | — | — | 1 | 6.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4465880 | — | IC50 | = | 39.81 | nM | 7.40 |
| CHEMBL4577486 | — | IC50 | = | 50.12 | nM | 7.30 |
| CHEMBL4449894 | — | IC50 | = | 251.19 | nM | 6.60 |