Assay Detail
Binding
CHEMBL4359940
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant full length His6-tagged IRAK4 expressed in baculovirus expression system using H-KKARFSRFAGSSPSQSSMVAR as substrate incubated for 90 mins by fluorescence polarisation assay
36
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Interleukin-1 receptor-associated kinase 4 (CHEMBL3778) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Development of Potent and Selective Pyrazolopyrimidine IRAK4 Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 36 | 8.19 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4474636 | — | — | 1 | 9.30 |
| CHEMBL4464832 | — | — | 1 | 9.30 |
| CHEMBL4568867 | — | — | 1 | 9.10 |
| CHEMBL4520118 | — | — | 1 | 8.96 |
| CHEMBL4515682 | — | — | 1 | 8.92 |
| CHEMBL4467170 | — | — | 1 | 8.82 |
| CHEMBL4460055 | — | — | 1 | 8.77 |
| CHEMBL4453861 | — | — | 1 | 8.77 |
| CHEMBL4483477 | — | — | 1 | 8.74 |
| CHEMBL3950656 | — | — | 1 | 8.70 |
| CHEMBL4483551 | — | — | 1 | 8.68 |
| CHEMBL4461516 | — | — | 1 | 8.49 |
| CHEMBL4466092 | — | — | 1 | 8.49 |
| CHEMBL4438027 | — | — | 1 | 8.46 |
| CHEMBL4466517 | — | — | 1 | 8.29 |
| CHEMBL4473269 | — | — | 1 | 8.28 |
| CHEMBL4531013 | — | — | 1 | 8.24 |
| CHEMBL4456286 | — | — | 1 | 8.21 |
| CHEMBL4518559 | — | — | 1 | 8.19 |
| CHEMBL4584820 | — | — | 1 | 8.18 |
| CHEMBL4554579 | — | — | 1 | 8.17 |
| CHEMBL4576141 | — | — | 1 | 8.14 |
| CHEMBL4524886 | — | — | 1 | 8.13 |
| CHEMBL4452936 | — | — | 1 | 8.00 |
| CHEMBL4459509 | — | — | 1 | 7.92 |
| CHEMBL4569547 | — | — | 1 | 7.89 |
| CHEMBL4439253 | — | — | 1 | 7.82 |
| CHEMBL4551768 | — | — | 1 | 7.58 |
| CHEMBL4462969 | — | — | 1 | 7.51 |
| CHEMBL4474664 | — | — | 1 | 7.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4474636 | — | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL4464832 | — | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL4568867 | — | Ki | = | 0.8 | nM | 9.10 |
| CHEMBL4520118 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL4515682 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL4467170 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL4460055 | — | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL4453861 | — | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL4483477 | — | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL3950656 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL4483551 | — | Ki | = | 2.1 | nM | 8.68 |
| CHEMBL4461516 | — | Ki | = | 3.2 | nM | 8.49 |
| CHEMBL4466092 | — | Ki | = | 3.2 | nM | 8.49 |
| CHEMBL4438027 | — | Ki | = | 3.5 | nM | 8.46 |
| CHEMBL4466517 | — | Ki | = | 5.1 | nM | 8.29 |
| CHEMBL4473269 | — | Ki | = | 5.3 | nM | 8.28 |
| CHEMBL4531013 | — | Ki | = | 5.8 | nM | 8.24 |
| CHEMBL4456286 | — | Ki | = | 6.1 | nM | 8.21 |
| CHEMBL4518559 | — | Ki | = | 6.5 | nM | 8.19 |
| CHEMBL4584820 | — | Ki | = | 6.6 | nM | 8.18 |
| CHEMBL4554579 | — | Ki | = | 6.7 | nM | 8.17 |
| CHEMBL4576141 | — | Ki | = | 7.3 | nM | 8.14 |
| CHEMBL4524886 | — | Ki | = | 7.4 | nM | 8.13 |
| CHEMBL4452936 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL4459509 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL4569547 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL4439253 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL4551768 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL4462969 | — | Ki | = | 31.0 | nM | 7.51 |
| CHEMBL4474664 | — | Ki | = | 34.0 | nM | 7.47 |
| CHEMBL4550566 | — | Ki | = | 35.0 | nM | 7.46 |
| CHEMBL3952937 | — | Ki | = | 52.0 | nM | 7.28 |
| CHEMBL4436128 | — | Ki | = | 95.0 | nM | 7.02 |
| CHEMBL4544284 | — | Ki | = | 170.0 | nM | 6.77 |
| CHEMBL4460458 | — | Ki | = | 290.0 | nM | 6.54 |
| CHEMBL4463353 | — | Ki | > | 8400.0 | nM | - |