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Assay Detail

CHEMBL4360799

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Functional
Antiviral activity against Human rhinovirus A2
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism rhinovirus A2
Confidence 1 — Organism
Curated By Autocuration

Target

rhinovirus A2 (CHEMBL612678)
Type ORGANISM
Organism rhinovirus A2

Publication

Back to the future: Advances in development of broad-spectrum capsid-binding inhibitors of enteroviruses.
Egorova A, Ekins S, Schmidtke M, Makarov V.
Eur J Med Chem (2019) 178 : 606 -622
PubMed 31226653 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 19 7.64 8.40

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL283639 DISOXARIL 2.0 1 8.40
CHEMBL96339 1 8.05
CHEMBL320168 1 8.05
CHEMBL328858 1 8.05
CHEMBL230440 1 8.05
CHEMBL395062 1 8.05
CHEMBL396266 1 8.05
CHEMBL397439 1 8.05
CHEMBL231280 1 8.05
CHEMBL231378 1 8.05
CHEMBL397440 1 8.05
CHEMBL4541546 1 8.05
CHEMBL4469987 1 7.40
CHEMBL6641 1 7.40
CHEMBL6824 1 7.40
CHEMBL25488 1 7.00
CHEMBL266800 1 7.00
CHEMBL28442 1 6.05
CHEMBL293278 1 6.05

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL283639 DISOXARIL IC50 = 4.0 nM 8.40
CHEMBL96339 IC50 = 9.0 nM 8.05
CHEMBL320168 IC50 = 9.0 nM 8.05
CHEMBL328858 IC50 = 9.0 nM 8.05
CHEMBL230440 IC50 = 9.0 nM 8.05
CHEMBL395062 IC50 = 9.0 nM 8.05
CHEMBL396266 IC50 = 9.0 nM 8.05
CHEMBL397439 IC50 = 9.0 nM 8.05
CHEMBL231280 IC50 = 9.0 nM 8.05
CHEMBL231378 IC50 = 9.0 nM 8.05
CHEMBL397440 IC50 = 9.0 nM 8.05
CHEMBL4541546 IC50 = 9.0 nM 8.05
CHEMBL4469987 IC50 = 40.0 nM 7.40
CHEMBL6641 IC50 = 40.0 nM 7.40
CHEMBL6824 IC50 = 40.0 nM 7.40
CHEMBL25488 IC50 = 100.0 nM 7.00
CHEMBL266800 IC50 = 100.0 nM 7.00
CHEMBL28442 IC50 = 900.0 nM 6.05
CHEMBL293278 IC50 = 900.0 nM 6.05