Assay Detail
Binding
CHEMBL4361465
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human full-length JNK3 using ATF2 as substrate measured after 40 mins in presence of [gamma33P]ATP by scintillation counting analysis
46
Total Activities
46
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Multistage Screening Reveals 3-Substituted Indolin-2-one Derivatives as Novel and Isoform-Selective c-Jun N-terminal Kinase 3 (JNK3) Inhibitors: Implications to Drug Discovery for Potential Treatment of Neurodegenerative Diseases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 46 | 5.89 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4470981 | — | — | 1 | 7.40 |
| CHEMBL4462592 | — | — | 1 | 7.05 |
| CHEMBL3355181 | — | — | 1 | 6.69 |
| CHEMBL4531109 | — | — | 1 | 6.60 |
| CHEMBL4531954 | — | — | 1 | 6.46 |
| CHEMBL4551217 | — | — | 1 | 6.23 |
| CHEMBL4464624 | — | — | 1 | 6.21 |
| CHEMBL4442806 | — | — | 1 | 6.12 |
| CHEMBL4451516 | — | — | 1 | 5.74 |
| CHEMBL4470329 | — | — | 1 | 5.72 |
| CHEMBL4483382 | — | — | 1 | 5.62 |
| CHEMBL4579302 | — | — | 1 | 5.61 |
| CHEMBL4533188 | — | — | 1 | 5.37 |
| CHEMBL1213862 | — | — | 1 | 5.18 |
| CHEMBL4449405 | — | — | 1 | 5.12 |
| CHEMBL4560317 | — | — | 1 | 5.05 |
| CHEMBL4483514 | — | — | 1 | 5.01 |
| CHEMBL4461363 | — | — | 1 | 4.85 |
| CHEMBL4473294 | — | — | 1 | - |
| CHEMBL4555937 | — | — | 1 | - |
| CHEMBL4515438 | — | — | 1 | - |
| CHEMBL4460138 | — | — | 1 | - |
| CHEMBL4556088 | — | — | 1 | - |
| CHEMBL4474891 | — | — | 1 | - |
| CHEMBL4434675 | — | — | 1 | - |
| CHEMBL4570907 | — | — | 1 | - |
| CHEMBL4445231 | — | — | 1 | - |
| CHEMBL4525711 | — | — | 1 | - |
| CHEMBL4593699 | — | — | 1 | - |
| CHEMBL4476142 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4470981 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL4462592 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL3355181 | — | IC50 | = | 206.0 | nM | 6.69 |
| CHEMBL4531109 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL4531954 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL4551217 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL4464624 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL4442806 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL4451516 | — | IC50 | = | 1830.0 | nM | 5.74 |
| CHEMBL4470329 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL4483382 | — | IC50 | = | 2370.0 | nM | 5.62 |
| CHEMBL4579302 | — | IC50 | = | 2430.0 | nM | 5.61 |
| CHEMBL4533188 | — | IC50 | = | 4240.0 | nM | 5.37 |
| CHEMBL1213862 | — | IC50 | = | 6570.0 | nM | 5.18 |
| CHEMBL4449405 | — | IC50 | = | 7650.0 | nM | 5.12 |
| CHEMBL4560317 | — | IC50 | = | 8890.0 | nM | 5.05 |
| CHEMBL4483514 | — | IC50 | = | 9760.0 | nM | 5.01 |
| CHEMBL4461363 | — | IC50 | = | 14190.0 | nM | 4.85 |
| CHEMBL4447936 | — | IC50 | - | — | - | |
| CHEMBL4483365 | — | IC50 | - | — | - | |
| CHEMBL4535734 | — | IC50 | - | — | - | |
| CHEMBL4586410 | — | IC50 | - | — | - | |
| CHEMBL4453686 | — | IC50 | - | — | - | |
| CHEMBL4470258 | — | IC50 | - | — | - | |
| CHEMBL4459794 | — | IC50 | - | — | - | |
| CHEMBL4437644 | — | IC50 | - | — | - | |
| CHEMBL4448246 | — | IC50 | - | — | - | |
| CHEMBL4535812 | — | IC50 | - | — | - | |
| CHEMBL4568701 | — | IC50 | - | — | - | |
| CHEMBL4465560 | — | IC50 | - | — | - | |
| CHEMBL4440357 | — | IC50 | - | — | - | |
| CHEMBL4443376 | — | IC50 | - | — | - | |
| CHEMBL4583209 | — | IC50 | - | — | - | |
| CHEMBL4448371 | — | IC50 | - | — | - | |
| CHEMBL4476142 | — | IC50 | - | — | - | |
| CHEMBL4593699 | — | IC50 | - | — | - | |
| CHEMBL4525711 | — | IC50 | - | — | - | |
| CHEMBL4445231 | — | IC50 | - | — | - | |
| CHEMBL4570907 | — | IC50 | - | — | - | |
| CHEMBL4434675 | — | IC50 | - | — | - | |
| CHEMBL4474891 | — | IC50 | - | — | - | |
| CHEMBL4556088 | — | IC50 | - | — | - | |
| CHEMBL4460138 | — | IC50 | - | — | - | |
| CHEMBL4515438 | — | IC50 | - | — | - | |
| CHEMBL4555937 | — | IC50 | - | — | - | |
| CHEMBL4473294 | — | IC50 | - | — | - |