Assay Detail
Binding
CHEMBL4361671
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant untagged p38alpha expressed in Escherichia coli using ATF2 as substrate incubated for 60 mins in presence of [33P]-ATP by radiometric assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis, and antifibrosis evaluation of 4-(benzo-[c][1,2,5]thiadiazol-5-yl)-3(5)-(6-methyl- pyridin-2-yl)pyrazole and 3(5)-(6-methylpyridin- 2-yl)-4-(thieno-[3,2,-c]pyridin-2-yl)pyrazole derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 5.41 | 6.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2364611 | GALUNISERTIB | 2.0 | 1 | 6.31 |
| CHEMBL3260567 | VACTOSERTIB | 2.0 | 1 | 5.66 |
| CHEMBL4461256 | — | — | 1 | 5.42 |
| CHEMBL4594036 | — | — | 1 | 5.24 |
| CHEMBL4527908 | — | — | 1 | 5.15 |
| CHEMBL4576703 | — | — | 1 | 5.09 |
| CHEMBL4513885 | — | — | 1 | 5.02 |
| CHEMBL4569982 | — | — | 1 | - |
| CHEMBL4530888 | — | — | 1 | - |
| CHEMBL4471215 | — | — | 1 | - |
| CHEMBL4474331 | — | — | 1 | - |
| CHEMBL4455044 | — | — | 1 | - |
| CHEMBL4460586 | — | — | 1 | - |
| CHEMBL4520187 | — | — | 1 | - |
| CHEMBL4531718 | — | — | 1 | - |
| CHEMBL4570292 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2364611 | GALUNISERTIB | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL3260567 | VACTOSERTIB | IC50 | = | 2180.0 | nM | 5.66 |
| CHEMBL4461256 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL4594036 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL4527908 | — | IC50 | = | 7040.0 | nM | 5.15 |
| CHEMBL4576703 | — | IC50 | = | 8120.0 | nM | 5.09 |
| CHEMBL4513885 | — | IC50 | = | 9460.0 | nM | 5.02 |
| CHEMBL4569982 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4530888 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4471215 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4474331 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4455044 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4460586 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4520187 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4531718 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4570292 | — | IC50 | > | 10000.0 | nM | - |