Assay Detail
Binding
CHEMBL4361964
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of 17beta-HSD2 in human MDA-MB-231 cells using [3H]-E2 as substrate after 6 hrs by radio-HPLC analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-231 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
17-beta-hydroxysteroid dehydrogenase type 2 (CHEMBL2789) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design, Synthesis, and Biological Characterization of Orally Active 17β-Hydroxysteroid Dehydrogenase Type 2 Inhibitors Targeting the Prevention of Osteoporosis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.43 | 8.02 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4513439 | — | — | 1 | 8.02 |
| CHEMBL4447938 | — | — | 1 | 7.33 |
| CHEMBL4518587 | — | — | 1 | 7.32 |
| CHEMBL4441313 | — | — | 1 | 7.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4513439 | — | IC50 | = | 9.6 | nM | 8.02 |
| CHEMBL4447938 | — | IC50 | = | 46.3 | nM | 7.33 |
| CHEMBL4518587 | — | IC50 | = | 48.4 | nM | 7.32 |
| CHEMBL4441313 | — | IC50 | = | 87.2 | nM | 7.06 |