Assay Detail
Binding
CHEMBL4361992
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Inhibition of human serum BuChe by Ellman's method
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Tacrine-O-protected phenolics heterodimers as multitarget-directed ligands against Alzheimer's disease: Selective subnanomolar BuChE inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 7.84 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4545701 | — | — | 1 | 9.30 |
| CHEMBL4555120 | — | — | 1 | 9.29 |
| CHEMBL4475228 | — | — | 1 | 8.54 |
| CHEMBL4531167 | — | — | 1 | 8.22 |
| CHEMBL4588525 | — | — | 1 | 8.16 |
| CHEMBL4572757 | — | — | 1 | 7.64 |
| CHEMBL4589250 | — | — | 1 | 7.45 |
| CHEMBL4536715 | — | — | 1 | 7.38 |
| CHEMBL95 | TACRINE | 4.0 | 1 | 7.36 |
| CHEMBL4535585 | — | — | 1 | 7.13 |
| CHEMBL4521755 | — | — | 1 | 6.92 |
| CHEMBL4439554 | — | — | 1 | 6.71 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4545701 | — | IC50 | = | 0.497 | nM | 9.30 |
| CHEMBL4555120 | — | IC50 | = | 0.515 | nM | 9.29 |
| CHEMBL4475228 | — | IC50 | = | 2.92 | nM | 8.54 |
| CHEMBL4531167 | — | IC50 | = | 6.06 | nM | 8.22 |
| CHEMBL4588525 | — | IC50 | = | 6.95 | nM | 8.16 |
| CHEMBL4572757 | — | IC50 | = | 22.9 | nM | 7.64 |
| CHEMBL4589250 | — | IC50 | = | 35.6 | nM | 7.45 |
| CHEMBL4536715 | — | IC50 | = | 41.5 | nM | 7.38 |
| CHEMBL95 | TACRINE | IC50 | = | 44.2 | nM | 7.36 |
| CHEMBL4535585 | — | IC50 | = | 74.8 | nM | 7.13 |
| CHEMBL4521755 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL4439554 | — | IC50 | = | 194.0 | nM | 6.71 |